Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural basis of leukotriene B4 receptor 1 activation

3 Mar 2022

Abstract excerpt

Abstract Leukotriene B4 receptor 1 (BLT1) plays crucial roles in the acute inflammatory responses and is a valuable target for anti-inflammation treatment, however, the mechanism by which leukotriene B4 (LTB4) activates receptor remains unclear. Here, we report the cryo-electron microscopy (cryo-EM) structure of the LTB4 -bound human BLT1 in complex with a Gi protein in an active conformation at resolution of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Asthma and respiratory diseases
Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35241677
DOI: 10.1038/s41467-022-28820-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural basis of leukotriene B4 receptor 1 activationPMID 35241677Read ↗

Engineering a G protein-coupled receptor for structural studies: stabilization of the BLT1 receptor ground state.Semantic proximity Read ↗

Structure of the receptor-activated human TRPC6 ion channelSemantic proximity Read ↗

Structure of formylpeptide receptor 2-Gi complex reveals insights into ligand recognition and signaling.Semantic proximity Read ↗

Expression, purification and characterization of leukotriene B(4) receptor, BLT1 in Pichia pastoris.Semantic proximity Read ↗

Cryo-EM structure of the human histamine H1 receptor/Gq complexSemantic proximity Read ↗

Structural insights into the conformational changes of BTR1/SLC4A11 in complex with PIP2.Semantic proximity Read ↗

Structural Diversity and Mutational Challenges of Toll-Like Receptor 4 Antagonists as Inflammatory Pathway Blocker.Semantic proximity Read ↗

Structural basis of odorant recognition by a human odorant receptorSemantic proximity Read ↗

TRPML1 gating modulation by allosteric mutations and lipids.Semantic proximity Read ↗

Structural and functional insights into the lipid regulation of human anion exchanger 2.Semantic proximity Read ↗

Structure of a lasso peptide bound ETB receptor provides insights into the mechanism of GPCR inverse agonismSemantic proximity Read ↗

Structures of ABCB4 provide insight into phosphatidylcholine translocation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.