Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Engineering a G protein-coupled receptor for structural studies: stabilization of the BLT1 receptor ground state.

Protein science : a publication of the Protein Society - 1 Apr 2009

Martin Aimée, Damian Marjorie, Laguerre Michel, Parello Joseph, Pucci Bernard, Serre Laurence, Mary Sophie, Marie Jacky, Banères Jean-Louis

Abstract excerpt

Structural characterization of membrane proteins is hampered by their instability in detergent solutions. We modified here a G protein-coupled receptor, the BLT1 receptor of leukotriene B(4), to stabilize it in vitro. For this, we introduced a metal-binding site connecting the third and sixth tra...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Detergents
Share to GTP-Binding Proteins
Share to Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Conformation

Share to Protein Stability

Share to Sequence Alignment

Share to Temperature

Source

Open in PubMed Open full text

Identifiers

PMID: 19309698
DOI: 10.1002/pro.55
PMCID: PMC2762585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19309698-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Engineering a G protein-coupled receptor for structural studies: stabilization of the BLT1 receptor ground state.PMID 19309698Read ↗

Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1.Semantic proximity Read ↗

Structural basis of leukotriene B4 receptor 1 activationSemantic proximity Read ↗

Conformational thermostabilization of the beta1-adrenergic receptor in a detergent-resistant form.Semantic proximity Read ↗

Structural determinants regulating expression of the high affinity leukotriene B4 receptor: involvement of dileucine motifs and alpha-helix VIII.Semantic proximity Read ↗

Understanding single-pass transmembrane receptor signaling from a structural viewpoint-what are we missing?Semantic proximity Read ↗

Helix 8 of the leukotriene B4 receptor is required for the conformational change to the low affinity state after G-protein activation.Semantic proximity Read ↗

Decoding the structure of GPR151 via NELiS.Semantic proximity Read ↗

Reprogramming G protein coupled receptor structure and function.Semantic proximity Read ↗

A crystal clear solution for determining G-protein-coupled receptor structures.Semantic proximity Read ↗

Universal platform for the generation of thermostabilized GPCRs that crystallize in LCP.Semantic proximity Read ↗

Thermostabilisation of an agonist-bound conformation of the human adenosine A(2A) receptor.Semantic proximity Read ↗

Expression, purification and characterization of leukotriene B(4) receptor, BLT1 in Pichia pastoris.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.