Article
Molecular genetic changes associated with ovarian cancer.
Gynecologic oncology - 1 Nov 1994
Weitzel J N, Patel J, Smith D M, Goodman A, Safaii H, Ball H G
Abstract excerpt
Multiple specific chromosomal deletions can be found in human epithelial ovarian cancer by cytogenetic analysis or molecular techniques. Somatic allelic deletion or loss of heterozygosity (LOH) in a tumor is considered circumstantial evidence for the location of tumor suppressor genes. We have examined 27 primary epithelial ovarian tumors for the presence of LOH at 19 polymorphic markers on chromosomes 1, 5, 6,...
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