Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas.

Article

Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas.

Cancer research - 1 May 1990

Lee J H, Kavanagh J J, Wildrick D M, Wharton J T, Blick M

Abstract excerpt

Recently, tumor-specific allele loss has been shown to be an important characteristic of some tumors. When such loss includes one or more growth-regulatory genes, it may allow the expression of tumorigenicity. Using Southern blots, we analyzed normal and tumor DNA samples from 19 ovarian cancer p...

Topics

Alleles
Chromosome Aberrations
Chromosomes, Human, Pair 11
Chromosomes, Human, Pair 17
Chromosomes, Human, Pair 6
Female
Heterozygote
Humans
Ovarian Neoplasms
Receptors, Estrogen

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