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Article

Analysis of loss of heterozygosity and KRAS2 mutations in ovarian neoplasms: clinicopathological correlations.

Genes, chromosomes & cancer - 1 Feb 1997

Chenevix-Trench G, Kerr J, Hurst T, Shih Y C, Purdie D, Bergman L, Friedlander M, Sanderson B, Zournazi A, Coombs T, Leary J A, Crawford E, Shelling A N, Cooke I, Ganesan T S, Searle J, Choi C, Barrett J C, Khoo S K, Ward B

Abstract excerpt

The molecular events that give rise to ovarian epithelial neoplasms are not well understood. In particular, it is not known whether adenocarcinomas arise from benign or low malignant potential (LMP) precursors. We have examined a large series of benign (25) and LMP (31) ovarian tumors for loss of heterozygosity (LOH) at multiple loci on 17 chromosomes. LOH was observed in benign tumors on chromosomes 6 (14%) and...

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PMID: 9115967
DOI: 10.1002/(sici)1098-2264(199702)18:2<75::aid-gcc1>3.0.co;2-y

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Source receipt: pubmed, retrieved 7 Sept 2026.

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