Article
Analysis of loss of heterozygosity and KRAS2 mutations in ovarian neoplasms: clinicopathological correlations.
Genes, chromosomes & cancer - 1 Feb 1997
Chenevix-Trench G, Kerr J, Hurst T, Shih Y C, Purdie D, Bergman L, Friedlander M, Sanderson B, Zournazi A, Coombs T, Leary J A, Crawford E, Shelling A N, Cooke I, Ganesan T S, Searle J, Choi C, Barrett J C, Khoo S K, Ward B
Abstract excerpt
The molecular events that give rise to ovarian epithelial neoplasms are not well understood. In particular, it is not known whether adenocarcinomas arise from benign or low malignant potential (LMP) precursors. We have examined a large series of benign (25) and LMP (31) ovarian tumors for loss of...
Topics
- Chromosome Deletion
- Female
- Genes, ras
- Heterozygote
- Humans
- Mutation
- Neoplasm Staging
- Ovarian Neoplasms
- Survival Analysis