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Article

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.

The Journal of biological chemistry - 12 Mar 2004

Batten Matthew L, Imanishi Yoshikazu, Maeda Tadao, Tu Daniel C, Moise Alexander R, Bronson Darin, Possin Daniel, Van Gelder Russell N, Baehr Wolfgang, Palczewski Krzysztof

Abstract excerpt

Lecithin-retinol acyltransferase (LRAT), an enzyme present mainly in the retinal pigmented epithelial cells and liver, converts all-trans-retinol into all-trans-retinyl esters. In the retinal pigmented epithelium, LRAT plays a key role in the retinoid cycle, a two-cell recycling system that replenishes the 11-cis-retinal chromophore of rhodopsin and cone pigments. We disrupted mouse Lrat gene expression by...

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Identifiers

PMID: 14684738
DOI: 10.1074/jbc.M312410200
PMCID: PMC1351249

Genes

LRAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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