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Article

Severe ocular phenotypes in Rbp4-deficient mice in the C57BL/6 genetic background.

Laboratory investigation; a journal of technical methods and pathology - 1 Jun 2016

Shen Jingling, Shi Dan, Suzuki Tomohiro, Xia Zunping, Zhang Hanli, Araki Kimi, Wakana Shigeharu, Takeda Naoki, Yamamura Ken-Ichi, Jin Shoude, Li Zhenghua

Abstract excerpt

Retinol-binding protein 4 (RBP4) is a specific carrier for retinol in the blood. In hepatocytes, newly synthesized RBP4 associates with retinol and transthyretin and is secreted into the blood. The ternary transthyretin-RBP4-retinol complex transports retinol in the circulation and delivers it to target tissues. Rbp4-deficient mice in a mixed genetic background (129xC57BL/6J) have decreased sensitivity to light...

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Source

Identifiers

PMID: 26974396
DOI: 10.1038/labinvest.2016.39

Genes

RBP4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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