Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Feb 2013

Li Songhua, Lee Jungsoo, Zhou Yongdong, Gordon William C, Hill James M, Bazan Nicolas G, Miner Jeffrey H, Jin Minghao

Abstract excerpt

Although rhodopsin is essential for sensing light for vision, it also mediates light-induced apoptosis of photoreceptors in mouse. RPE65, which catalyzes isomerization of all-trans retinyl fatty acid esters to 11-cis-retinol (11cROL) in the visual cycle, controls the rhodopsin regeneration rate and photoreceptor susceptibility to light-induced degeneration. Mutations in RPE65 have been linked to blindness in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alcohol Oxidoreductases
Share to cis-trans-Isomerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fatty Acid Elongases

Share to Fatty Acid Transport Proteins

Share to Peptide Chain Elongation, Translational

Share to Retinal Cone Photoreceptor Cells

Share to Retinal Rod Photoreceptor Cells

Share to Retinoids

Source

Open in PubMed Open full text

Identifiers

PMID: 23407971
DOI: 10.1523/JNEUROSCI.2428-12.2013
PMCID: PMC3625017

Genes

RPE65
RPE
ELOVL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fatty acid transport protein 4 (FATP4) prevents light-induced degeneration of cone and rod photoreceptors by inhibiting RPE65 isomerase.PMID 23407971Read ↗

FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase.Semantic proximity Read ↗

Inverse correlation between fatty acid transport protein 4 and vision in Leber congenital amaurosis associated with RPE65 mutation.Semantic proximity Read ↗

Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.Semantic proximity Read ↗

RPE Visual Cycle and Biochemical Phenotypes of Mutant Mouse Models.Semantic proximity Read ↗

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.Semantic proximity Read ↗

Role of ELOVL4 and very long-chain polyunsaturated fatty acids in mouse models of Stargardt type 3 retinal degeneration.Semantic proximity Read ↗

Current Progress in Deciphering Importance of VLC-PUFA in the Retina.Semantic proximity Read ↗

The Elovl4 Spinocerebellar Ataxia-34 Mutation 736T>G (p.W246G) Impairs Retinal Function in the Absence of Photoreceptor Degeneration.Semantic proximity Read ↗

Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function.Semantic proximity Read ↗

Lysophosphatidylcholine acyltransferase 1 controls the mitochondrial reactive oxygen species generation and survival of the retinal photoreceptor cellsSemantic proximity Read ↗

Drosophila fatty acid transport protein regulates rhodopsin-1 metabolism and is required for photoreceptor neuron survival.Semantic proximity Read ↗

Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.