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Article

Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency.

The Journal of biological chemistry - 2 Dec 2005

Liu Limin, Gudas Lorraine J

Abstract excerpt

Lecithin:retinol acyltransferase (LRAT) catalyzes the esterification of retinol (vitamin A) in the liver and in some extrahepatic tissues, including the lung. We produced an LRAT gene knock-out mouse strain and assessed whether LRAT-/- mice were more susceptible to vitamin A deficiency than wild type (WT) mice. After maintenance on a vitamin A-deficient diet for 6 weeks, the serum retinol level was 1.34 +/- 0.32...

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Source

Identifiers

PMID: 16174770
DOI: 10.1074/jbc.M509643200

Genes

LRAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency.PMID 16174770Read ↗

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