Article
Comparison of ocular pathologies in vitamin A-deficient mice and RPE65 gene knockout mice.
Investigative ophthalmology & visual science - 25 Jul 2011
Hu Yang, Chen Ying, Moiseyev Gennadiy, Takahashi Yusuke, Mott Robert, Ma Jian-Xing
Abstract excerpt
PURPOSE: RPE65 gene knockout (Rpe65⁻/⁻) mice showed abolished isomerohydrolase activity in the visual cycle and were considered a model for vitamin A deficiency in the retina. The purpose of this study was to compare the retinal phenotypes between vitamin A-deficient (VAD) mice and Rpe65⁻/⁻ mice under normal diet. METHODS: The VAD mice were fed with a vitamin A-deprived diet after birth. The age-matched control...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.