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Article

Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage.

Investigative ophthalmology & visual science - 1 Dec 2007

Ruiz Alberto, Ghyselinck Norbert B, Mata Nathan, Nusinowitz Steven, Lloyd Marcia, Dennefeld Christine, Chambon Pierre, Bok Dean

Abstract excerpt

PURPOSE: To generate a mouse model in which the Lrat gene is selectively disrupted in the retinal pigment epithelium (RPE). To evaluate the effects on the synthesis of retinyl esters and on the expression of other proteins involved in the continuation of the visual cycle. METHODS: A mouse line in which part of the first exon of the Lrat gene has been flanked by loxP sites, was generated and used in the study...

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Source

Identifiers

PMID: 18055784
DOI: 10.1167/iovs.07-0673

Genes

RPE
ERG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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