Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function.

doi:10.3390/nu8110746

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Article

Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function.

Nutrients - 22 Nov 2016

Sahu Bhubanananda, Maeda Akiko

Abstract excerpt

The visual system produces visual chromophore, 11-cis-retinal from dietary vitamin A, all-trans-retinol making this vitamin essential for retinal health and function. These metabolic events are mediated by a sequential biochemical process called the visual cycle. Retinol dehydrogenases (RDHs) are responsible for two reactions in the visual cycle performed in retinal pigmented epithelial (RPE) cells, photoreceptor...

Topics

Alcohol Oxidoreductases
Animals
Ependymoglial Cells
Genetic Predisposition to Disease
Humans
Mutation
Oxidation-Reduction
Phenotype
Retinal Diseases
Retinal Pigment Epithelium
Retinal Rod Photoreceptor Cells
Retinaldehyde
Vision, Ocular
Vitamin A

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PMID: 27879662
DOI: 10.3390/nu8110746
PMCID: PMC5133129

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