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Article

Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse.

Endocrinology - 1 Apr 2004

Hewitt Kylie N, Pratis Kyriakos, Jones Margaret E E, Simpson Evan R

Abstract excerpt

The aromatase knockout (ArKO) mouse cannot synthesize endogenous estrogens due to a disruption to the Cyp19 gene. Previously we have shown both male and female ArKO mice have an age progressive obese phenotype and a sexually dimorphic disruption to hepatic cholesterol and triglyceride homeostasis. Only ArKO males have elevated hepatic triglyceride levels leading to hepatic steatosis partly due to an increase in...

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Identifiers

PMID: 14684602
DOI: 10.1210/en.2003-1369

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estrogen replacement reverses the hepatic steatosis phenotype in the male aromatase knockout mouse.PMID 14684602Read ↗

Effect of estrogen deficiency in the male: the ArKO mouse model.Semantic proximity Read ↗

Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity.Semantic proximity Read ↗

Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse.Semantic proximity Read ↗

Sexual dimorphism in the glucose homeostasis phenotype of the Aromatase Knockout (ArKO) mice.Semantic proximity Read ↗

Reduced fat mass in mice lacking orphan nuclear receptor estrogen-related receptor alpha.Semantic proximity Read ↗

The ovarian phenotype of the aromatase knockout (ArKO) mouse.Semantic proximity Read ↗

Genetic mutations resulting in loss of aromatase activity in humans and mice.Semantic proximity Read ↗

Hepatic adropin is regulated by estrogen and contributes to adverse metabolic phenotypes in ovariectomized mice.Semantic proximity Read ↗

An age-related ovarian phenotype in mice with targeted disruption of the Cyp 19 (aromatase) gene.Semantic proximity Read ↗

The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype.Semantic proximity Read ↗

Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.Semantic proximity Read ↗

Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice.Semantic proximity Read ↗

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