Article
Cellular and molecular characterization of the adipose phenotype of the aromatase-deficient mouse.
Endocrinology - 1 Apr 2003
Misso Marie L, Murata Yoko, Boon Wah Chin, Jones Margaret E E, Britt Kara L, Simpson Evan R
Abstract excerpt
Estrogen deficiency in the aromatase knockout (ArKO) mouse leads to the development of obesity by as early as 3 months of age, which is characterized by a marked increase in the weights of gonadal and infrarenal fat pads. Humans with natural mutations of the aromatase gene also develop a metabolic syndrome. In the present study cellular and molecular parameters were investigated in gonadal adipose tissue from...
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