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Article

The ovarian phenotype of the aromatase knockout (ArKO) mouse.

The Journal of steroid biochemistry and molecular biology - 1 Dec 2001

Britt K L, Drummond A E, Dyson M, Wreford N G, Jones M E, Simpson E R, Findlay J K

Abstract excerpt

Targeted disruption of exon 9 of the cyp19 gene gives rise to a non-functional aromatase enzyme incapable of converting androgens to oestrogens. The aromatase knockout (ArKO) mouse is, thus, characterised by a dysfunctional pituitary-gonadal axis, which manifests in non-detectable levels of oestrogen in serum. These mice also exhibit elevated levels of circulating gonadotrophins (luteinising hormone (LH) and...

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PMID: 11850223
DOI: 10.1016/s0960-0760(01)00158-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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