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Article

Effect of estrogen deficiency in the male: the ArKO mouse model.

Molecular and cellular endocrinology - 31 Jul 2002

Murata Y, Robertson K M, Jones M E E, Simpson E R

Abstract excerpt

Aromatase, the enzyme responsible for the conversion of androgens to estrogens, is present in the mouse gonads, brain, adipose tissue and bone. Depletion of endogenous estrogens in the aromatase deficient mouse (ArKO) caused by the targeted disruption of the Cyp19 gene resulted in an impairment of sexual behaviour and an age-dependent disruption of spermatogenesis. This disruption occurred during early...

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Identifiers

PMID: 12160996
DOI: 10.1016/s0303-7207(02)00090-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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