Article
The lack of estrogen and excess luteinizing hormone are responsible for the female ArKO mouse phenotype.
Molecular and cellular endocrinology - 7 Oct 2010
Liew Seng H, Drummond Ann E, Jones Margaret E, Findlay Jock K
Abstract excerpt
It remains to be established as to whether the absence of estrogen (direct) or the elevated levels of gonadotrophins and androgens (indirect) are responsible for the ArKO (aromatase knockout) ovarian phenotype. The aim of this study was to determine the effects of E(2) (17beta-estradiol) replacement, acyline (GnRH antagonist) and flutamide (anti-androgen) treatment on the ovarian phenotype of ArKO mice. E(2)...
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