Article
Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2000
Jones M E, Thorburn A W, Britt K L, Hewitt K N, Wreford N G, Proietto J, Oz O K, Leury B J, Robertson K M, Yao S, Simpson E R
Abstract excerpt
The aromatase-knockout (ArKO) mouse provides a useful model to examine the role that estrogens play in development and homeostasis in mammals. Lacking a functional Cyp19 gene, which encodes aromatase, the ArKO mouse cannot synthesize endogenous estrogens. We examined the adipose depots of male and female ArKO mice, observing that these animals progressively accumulate significantly more intraabdominal adipose...
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