Article
Aromatase-deficient (ArKO) mice have a phenotype of increased adiposity.
Proceedings of the National Academy of Sciences of the United States of America - 7 Nov 2000
Jones M E, Thorburn A W, Britt K L, Hewitt K N, Wreford N G, Proietto J, Oz O K, Leury B J, Robertson K M, Yao S, Simpson E R
Abstract excerpt
The aromatase-knockout (ArKO) mouse provides a useful model to examine the role that estrogens play in development and homeostasis in mammals. Lacking a functional Cyp19 gene, which encodes aromatase, the ArKO mouse cannot synthesize endogenous estrogens. We examined the adipose depots of male an...
Topics
Join the communities discussing this publication.