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Article

Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice.

Lipids - 1 May 2003

Egawa Tetsu, Toda Katsumi, Nemoto Yoshihisa, Ono Masafumi, Akisaw Naoaki, Saibara Toshiji, Hayashi Yoshihiro, Hiroi Makoto, Enzan Hideaki, Onishi Saburo

Abstract excerpt

Tamoxifen is a potent antagonist of estrogen, and hepatic steatosis is a frequent complication in adjuvant tamoxifen for breast cancer. Impaired hepatic FA beta-oxidation in peroxisomes, microsomes, and mitochondria results in progression of massive hepatic steatosis in estrogen deficiency. This impairment, although latent, is potentially serious: About 3% of the general population in the United States is now...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12880107
DOI: 10.1007/s11745-003-1093-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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