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Article

Testosterone suppresses the expression of regulatory enzymes of fatty acid synthesis and protects against hepatic steatosis in cholesterol-fed androgen deficient mice.

Life sciences - 30 Jul 2014

Kelly Daniel M, Nettleship Joanne E, Akhtar Samia, Muraleedharan Vakkat, Sellers Donna J, Brooke Jonathan C, McLaren David S, Channer Kevin S, Jones T Hugh

Abstract excerpt

AIMS: Non-alcoholic fatty liver disease and its precursor hepatic steatosis is common in obesity and type-2 diabetes and is associated with cardiovascular disease (CVD). Men with type-2 diabetes and/or CVD have a high prevalence of testosterone deficiency. Testosterone replacement improves key cardiovascular risk factors. The effects of testosterone on hepatic steatosis are not fully understood. MAIN METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24953607
DOI: 10.1016/j.lfs.2014.06.007

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ACACA
FASN

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