Article
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors.
Cancer research - 1 Dec 2003
Ikenoue Tsuneo, Hikiba Yohko, Kanai Fumihiko, Tanaka Yasuo, Imamura Jun, Imamura Takaaki, Ohta Miki, Ijichi Hideaki, Tateishi Keisuke, Kawakami Takayuki, Aragaki Jun, Matsumura Masayuki, Kawabe Takao, Omata Masao
Abstract excerpt
Mutations in the B-Raf gene have been reported in a number of human cancers, including colorectal carcinoma. More than 80% of the B-Raf mutations were V599E. Although other mutations have been reported, their functional consequences were unclear. Here, we examined the effect of colon tumor-associated B-Raf mutations within the kinase activation segment, including V599E, on extracellular signal-regulated kinase...
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