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Article

C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

Molecular cell - 13 Nov 2009

Karreth Florian A, DeNicola Gina M, Winter Stephen P, Tuveson David A

Abstract excerpt

Activating B-Raf mutations that deregulate the MAPK pathway commonly occur in cancer. Whether additional proteins modulate the enzymatic activity of oncogenic B-Raf is unknown. Here we show that the proto-oncogene C-Raf paradoxically inhibits B-Raf(V600E) kinase activity through the formation of B-Raf(V600E)-C-Raf complexes. Although all Raf family members associate with oncogenic B-Raf, this inhibitory effect is...

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Identifiers

PMID: 19917255
DOI: 10.1016/j.molcel.2009.10.017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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