C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

doi:10.1016/j.molcel.2009.10.017

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Article

C-Raf inhibits MAPK activation and transformation by B-Raf(V600E).

Molecular cell - 13 Nov 2009

Karreth Florian A, DeNicola Gina M, Winter Stephen P, Tuveson David A

Abstract excerpt

Activating B-Raf mutations that deregulate the MAPK pathway commonly occur in cancer. Whether additional proteins modulate the enzymatic activity of oncogenic B-Raf is unknown. Here we show that the proto-oncogene C-Raf paradoxically inhibits B-Raf(V600E) kinase activity through the formation of...

Topics

Animals
Benzenesulfonates
Blotting, Western
Cell Line
Cell Line, Tumor
Cell Proliferation
Cell Transformation, Neoplastic
Enzyme Activation
Humans
Immunoprecipitation
MAP Kinase Signaling System
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mitogen-Activated Protein Kinases

Mutation

NIH 3T3 Cells

Niacinamide

Phenylurea Compounds

Source

Open in PubMed

Identifiers

PMID: 19917255
DOI: 10.1016/j.molcel.2009.10.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19917255-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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