Article
Functional consequences of mutations in a putative Akt phosphorylation motif of B-raf in human cancers.
Molecular carcinogenesis - 1 May 2005
Ikenoue Tsuneo, Kanai Fumihiko, Hikiba Yohko, Tanaka Yasuo, Imamura Jun, Ohta Miki, Jazag Amarsanaa, Guleng Bayasi, Asaoka Yoshinari, Tateishi Keisuke, Kawakami Takayuki, Matsumura Masayuki, Kawabe Takao, Omata Masao
Abstract excerpt
Mutations in the B-raf gene have been reported in a number of human cancers, including melanoma and lung cancer. More than 80% of the reported B-raf mutations were V599E; however, non-V599E mutations have been frequently found in non-small cell lung cancers as compared with melanoma. Some non-V599E mutations have been found surrounding Thr439, which is thought likely to be one of the three Akt phosphorylation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.