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Article

Characterization of a novel oncogenic K-ras mutation in colon cancer.

Biochemical and biophysical research communications - 19 Jan 2007

Akagi Kiwamu, Uchibori Ryosuke, Yamaguchi Kensei, Kurosawa Keiko, Tanaka Yoichiro, Kozu Tomoko

Abstract excerpt

Activating mutations of RAS are frequently observed in subsets of human cancers, indicating that RAS activation is involved in tumorigenesis. Here, we identified and characterized a novel G to T transversion mutation of the K-ras gene at the third position of codon 19 (TTG) which substituted phenylalanine for leucine in 3 primary colon carcinomas. Biological and biochemical activity was examined using transformed...

Topics

Amino Acid Sequence
Base Sequence
Colonic Neoplasms
Genes, ras
Genetic Predisposition to Disease
Humans
Molecular Sequence Data
Mutation
Neoplasm Proteins
ras Proteins

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Identifiers

PMID: 17150185
DOI: 10.1016/j.bbrc.2006.11.091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17150185-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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