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Article

Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.

Molecular cancer therapeutics - 1 Aug 2007

Hao Honglin, Muniz-Medina Vanessa M, Mehta Heena, Thomas Nancy E, Khazak Vladimir, Der Channing J, Shields Janiel M

Abstract excerpt

Mutational activation of Ras and a key downstream effector of Ras, the B-Raf serine/threonine kinase, has been observed in melanomas and colorectal carcinomas. These observations suggest that inhibition of B-Raf activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase kinase (MEK) and the extracellular signal-regulated kinase MAPK cascade may be an effective approach for the...

Topics

Animals
Cell Communication
Cell Line, Tumor
Cell Proliferation
Colorectal Neoplasms
Enzyme Activation
Extracellular Signal-Regulated MAP Kinases
Humans
MAP Kinase Kinase Kinases
Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Nude

Mutant Proteins

Mutation

Protein Kinase Inhibitors

Proto-Oncogene Proteins B-raf

RNA, Small Interfering

Signal Transduction

Source

Identifiers

PMID: 17699719
DOI: 10.1158/1535-7163.MCT-06-0728

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17699719-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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