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Article

Context-dependent roles of mutant B-Raf signaling in melanoma and colorectal carcinoma cell growth.

Molecular cancer therapeutics - 1 Aug 2007

Hao Honglin, Muniz-Medina Vanessa M, Mehta Heena, Thomas Nancy E, Khazak Vladimir, Der Channing J, Shields Janiel M

Abstract excerpt

Mutational activation of Ras and a key downstream effector of Ras, the B-Raf serine/threonine kinase, has been observed in melanomas and colorectal carcinomas. These observations suggest that inhibition of B-Raf activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase kinase (MEK) and the extracellular signal-regulated kinase MAPK cascade may be an effective approach for the...

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Identifiers

PMID: 17699719
DOI: 10.1158/1535-7163.MCT-06-0728

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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