Article
Association of a genetic marker at the corticotropin-releasing hormone locus with behavioral inhibition.
Biological psychiatry - 15 Dec 2003
Smoller Jordan W, Rosenbaum Jerrold F, Biederman Joseph, Kennedy John, Dai Daisy, Racette Stephanie R, Laird Nan M, Kagan Jerome, Snidman Nancy, Hirshfeld-Becker Dina, Tsuang Ming T, Sklar Pamela B, Slaugenhaupt Susan A
Abstract excerpt
BACKGROUND: Behavioral inhibition to the unfamiliar (BI), a heritable temperamental profile involving an avoidant response to novel situations, may be an intermediate phenotype in the development of anxiety disorders. Corticotropin-releasing hormone (CRH) is a key mediator of the stress response...
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