Article
A quantitative trait locus influencing anxiety in the laboratory rat.
Genome research - 1 Apr 2002
Fernández-Teruel Alberto, Escorihuela Rosa M, Gray Jeffrey A, Aguilar Raúl, Gil Luis, Giménez-Llort Lydia, Tobeña Adolf, Bhomra Amarjit, Nicod Alison, Mott Richard, Driscoll Peter, Dawson Gerard R, Flint Jonathan
Abstract excerpt
A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of anxiety. Despite many years of research, definitive evidence that genetic effects operate in this way is lacking. The limited behavioral test regimes so far used in genetic mapping experiments and the lack of suitable...
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