Article

Genome-Wide Association Study in a Rat Model of Temperament Identifies Multiple Loci for Exploratory Locomotion and Anxiety-Like Traits

2022-07-13

Abstract excerpt

Common genetic factors likely contribute to multiple psychiatric diseases including mood and substance use disorders. Certain stable, heritable traits reflecting temperament, termed externalizing or internalizing, play a large role in modulating vulnerability to these disorders. To model these heritable tendencies, we selectively bred rats for high and low exploration in a novel environment (bred High Responders (...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 67c70b0a-8663-5f93-8103-0cc4a1f869ab
DOI: 10.1101/2022.07.12.499605

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-Wide Association Study in a Rat Model of Temperament Identifies Multiple Loci for Exploratory Locomotion and Anxiety-Like TraitsDOI 10.1101/2022.07.12.499605Read

Genetic Architecture of Addiction-Relevant Behaviors in Outbred Sprague-Dawley Rats Reveals Loci for Anxiety-Like and Nociceptive Traits.Semantic proximity Read

Genome-wide association study of open field behavior in outbred heterogeneous stock rats identifies multiple loci implicated in psychiatric disordersSemantic proximity Read

A quantitative trait locus influencing anxiety in the laboratory rat.Semantic proximity Read

Cerebellum Transcriptome of Mice Bred for High Voluntary Activity Offers Insights into Locomotor Control and Reward-Dependent Behaviors.Semantic proximity Read

Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders.Semantic proximity Read

Selective breeding for divergence in novelty-seeking traits: heritability and enrichment in spontaneous anxiety-related behaviors.Semantic proximity Read

Atp1a2 and Kcnj9 are candidate genes underlying sensitivity to oxycodone-induced locomotor activation and withdrawal-induced anxiety-like behaviors in C57BL/6 substrainsSemantic proximity Read

High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model.Semantic proximity Read

Genetic Influences on Brain Gene Expression in Rats Selected for Tameness and AggressionSemantic proximity Read

Genetic selection of two new rat lines displaying different levels of anxiety-related behaviors.Semantic proximity Read

Genetic influences on brain gene expression in rats selected for tameness and aggression.Semantic proximity Read

Identification of quantitative trait loci and candidate genes for an anxiolytic-like response to ethanol in BXD recombinant inbred strains.Semantic proximity Read