Article
The corticotropin-releasing hormone gene and behavioral inhibition in children at risk for panic disorder.
Biological psychiatry - 15 Jun 2005
Smoller Jordan W, Yamaki Lesley H, Fagerness Jesen A, Biederman Joseph, Racette Stephanie, Laird Nan M, Kagan Jerome, Snidman Nancy, Faraone Stephen V, Hirshfeld-Becker Dina, Tsuang Ming T, Slaugenhaupt Susan A, Rosenbaum Jerrold F, Sklar Pamela B
Abstract excerpt
BACKGROUND: Behavioral inhibition to the unfamiliar (BI) is a heritable temperamental phenotype involving the tendency to display fearful, avoidant, or shy behavior in novel situations. BI is a familial and developmental risk factor for panic and phobic anxiety disorders. We previously observed an association between BI and a microsatellite marker linked to the corticotropin releasing hormone (CRH) gene in...
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