Article
Effect of pentoxifylline on arachidonic acid metabolism, neutral lipid synthesis and accumulation during induction of the lipocyte phenotype by retinol in murine hepatic stellate cell.
Molecular and cellular biochemistry - 1 Dec 2003
Cardoso Carla C A, Paviani Ernani R, Cruz Lavínia A, Guma Fátima C R, Borojevic Radovan, Guaragna Regina M
Abstract excerpt
In liver fibrosis, the quiescent hepatic stellate cells (HSC) are activated to proliferate and express the activated myofibroblast phenotype, losing fat droplets and the stored vitamin A, and depositing more extracellular matrix. Therapeutic strategies for liver fibrosis are focused on HSC. Pentoxifylline (PTF), an analog of the methylxanthine, prevents the biochemical and histological changes associated with...
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