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Article

Highly permissive cell lines for subgenomic and genomic hepatitis C virus RNA replication.

Journal of virology - 1 Dec 2002

Blight Keril J, McKeating Jane A, Rice Charles M

Abstract excerpt

Hepatitis C virus (HCV) replication appears to be restricted to the human hepatoma cell line Huh-7, indicating that a favorable cellular environment exists within these cells. Although adaptive mutations in the HCV nonstructural proteins typically enhance the replicative capacity of subgenomic replicons in Huh-7 cells, replication can only be detected in a subpopulation of these cells. Here we show that...

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Share to Base Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphorylation

Share to RNA, Viral

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Source

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Identifiers

PMID: 12438626
DOI: 10.1128/jvi.76.24.13001-13014.2002
PMCID: PMC136668

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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