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Article

PKR-Dependent Mechanisms of Gene Expression from a Subgenomic Hepatitis C Virus Clone

4 Oct 2002

Abstract excerpt

Studies on hepatitis C virus (HCV) replication have been greatly advanced by the development of cell culture models for HCV known as replicon systems. The prototype replicon consists of a subgenomic HCV RNA in which the HCV structural region is replaced by the neomycin phosphotransferase II (NPTII) gene, and translation of the HCV proteins NS3 to NS5 is directed by the encephalomyocarditis virus (EMCV) internal...

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Identifiers

PMID: 12368306
DOI: 10.1128/jvi.76.21.10637-10653.2002

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