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Article

Nonhepatic cell lines HeLa and 293 support efficient replication of the hepatitis C virus genotype 2a subgenomic replicon.

Journal of virology - 1 Jan 2005

Kato Takanobu, Date Tomoko, Miyamoto Michiko, Zhao Zijiang, Mizokami Masashi, Wakita Takaji

Abstract excerpt

The hepatitis C virus (HCV) genotype 2a subgenomic replicon can replicate in two human non-hepatocyte-derived cell lines, HeLa and 293, with in vitro-transcribed replicon RNA. Sequencing analysis revealed that mutations in HCV-derived regions were not essential for replication in these cells, as some clones displayed no mutations.

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Identifiers

PMID: 15596851
DOI: 10.1128/JVI.79.1.592-596.2005
PMCID: PMC538706

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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