Article
Genetic risk variants in African Americans with multiple sclerosis.
Neurology - 16 Jul 2013
Isobe Noriko, Gourraud Pierre-Antoine, Harbo Hanne F, Caillier Stacy J, Santaniello Adam, Khankhanian Pouya, Maiers Martin, Spellman Stephen, Cereb Nezih, Yang SooYoung, Pando Marcelo J, Piccio Laura, Cross Anne H, De Jager Philip L, Cree Bruce A C, Hauser Stephen L, Oksenberg Jorge R
Abstract excerpt
OBJECTIVES: To assess the association of established multiple sclerosis (MS) risk variants in 3,254 African Americans (1,162 cases and 2,092 controls). METHODS: Human leukocyte antigen (HLA)-DRB1, HLA-DQB1, and HLA-A alleles were typed by molecular techniques. Single nucleotide polymorphism (SNP) genotyping was conducted for 76 MS-associated SNPs and 52 ancestry informative marker SNPs selected throughout the...
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