Article
HLA-DRB1 polymorphism and susceptibility to multiple sclerosis in the Middle East North Africa region: A systematic review and meta-analysis.
Journal of neuroimmunology - 15 Aug 2018
Mohajer Bahram, Abbasi Nooshin, Pishgar Farhad, Abdolalizadeh Amirhussein, Ebrahimi Hedyeh, Razaviyoun Taraneh, Mohebbi Farnam, Eskandarieh Sharareh, Sahraian Mohammad Ali
Abstract excerpt
This meta-analysis explores association of HLA-DRB1 alleles with MS risk in the Middle-east North Africa (MENA) countries. Divided into two groups of alleles (10 studies, 899 cases/1457 controls) and phenotypes (8 studies, 1,040 cases/1,256 controls), Odds ratios (ORs) of DRB1 distribution in MS subjects were assessed using Cochrane RevMan software. DRB1*15 demonstrated significant association with MS in both...
Topics
- Africa, Northern
- Female
- Genetic Predisposition to Disease
- HLA-DRB1 Chains
- Humans
- Male
- Middle East
- Multiple Sclerosis
- Polymorphism, Genetic