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Article

Uncoupling the roles of HLA-DRB1 and HLA-DRB5 genes in multiple sclerosis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Oct 2008

Caillier Stacy J, Briggs Farren, Cree Bruce A C, Baranzini Sergio E, Fernandez-Viña Marcelo, Ramsay Patricia P, Khan Omar, Royal Walter, Hauser Stephen L, Barcellos Lisa F, Oksenberg Jorge R

Abstract excerpt

Genetic susceptibility to multiple sclerosis (MS) is associated with the MHC located on chromosome 6p21. This signal maps primarily to a 1-Mb region encompassing the HLA class II loci, and it segregates often with the HLA-DQB1*0602, -DQA1*0102, -DRB1*1501, -DRB5*0101 haplotype. However, the identification of the true predisposing gene or genes within the susceptibility haplotype has been handicapped by the strong...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Encephalomyelitis, Autoimmune, Experimental

Share to Histocompatibility Antigens Class II

Share to HLA-DR Antigens

Share to HLA-DRB1 Chains

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Source

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Identifiers

PMID: 18832704
DOI: 10.4049/jimmunol.181.8.5473
PMCID: PMC4346327

Genes

AGER

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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