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Article

Refining the association of MHC with multiple sclerosis in African Americans.

Human molecular genetics - 1 Aug 2010

McElroy Joseph P, Cree Bruce A C, Caillier Stacy J, Gregersen Peter K, Herbert Joseph, Khan Omar A, Freudenberg Jan, Lee Annette, Bridges S Louis, Hauser Stephen L, Oksenberg Jorge R, Gourraud Pierre-Antoine

Abstract excerpt

Multiple sclerosis (MS) is a common demyelinating disease of the central nervous system mediated by autoimmune and neurodegenerative pathogenic mechanisms. Multiple genes account for its moderate heritability, but the only genetic region shown to have a large replicable effect on MS susceptibility is the major histocompatibility complex (MHC). Strong linkage disequilibrium (LD) across the MHC has made it...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20466734
DOI: 10.1093/hmg/ddq197
PMCID: PMC2901136

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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