Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.

Nature - 11 Dec 2003

Opferman Joseph T, Letai Anthony, Beard Caroline, Sorcinelli Mia D, Ong Christy C, Korsmeyer Stanley J

Abstract excerpt

Regulated apoptosis is essential for both the development and the subsequent maintenance of the immune system. Interleukins, including IL-2, IL-4, IL-7 and IL-15, heavily influence lymphocyte survival during the vulnerable stages of VDJ rearrangement and later in ensuring cellular homeostasis, but the genes specifically responsible for the development and maintenance of lymphocytes have not been identified. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Integrases
Share to Antigens, CD19
Share to Attachment Sites, Microbiological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Lineage

Share to Myeloid Cell Leukemia Sequence 1 Protein

Share to Proto-Oncogene Proteins c-bcl-2

Share to Spleen

Share to Thymus Gland

Source

Identifiers

PMID: 14668867
DOI: 10.1038/nature02067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development and maintenance of B and T lymphocytes requires antiapoptotic MCL-1.PMID 14668867Read ↗

Mcl-1 is a key regulator of apoptosis during CNS development and after DNA damage.Semantic proximity Read ↗

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude AutoimmunitySemantic proximity Read ↗

The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survivalSemantic proximity Read ↗

Bcl‐2 proteins in development, health, and disease of the hematopoietic systemSemantic proximity Read ↗

Loss of a Single Mcl-1 Allele Inhibits MYC-Driven Lymphomagenesis by Sensitizing Pro-B Cells to Apoptosis.Semantic proximity Read ↗

Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf.Semantic proximity Read ↗

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice.Semantic proximity Read ↗

Proapoptotic BIM Impacts B Lymphoid Homeostasis by Limiting the Survival of Mature B Cells in a Cell-Autonomous Manner.Semantic proximity Read ↗

Promoter knock-in mutations reveal a role of Mcl-1 in thymocyte-positive selection and tissue or cell lineage-specific regulation of Mcl-1 expression.Semantic proximity Read ↗

Apoptosis in the Homeostasis of the Immune System and in Human Immune Mediated DiseasesSemantic proximity Read ↗

Programmed cell death during animal developmentSemantic proximity Read ↗

Senescence and Apoptosis: Architects of Mammalian DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.