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Article

The BCL2A1 gene as a pre–T cell receptor–induced regulator of thymocyte survival

21 Feb 2005

Abstract excerpt

The pre-T cell receptor (TCR) is expressed early during T cell development and imposes a tight selection for differentiating T cell progenitors. Pre-TCR-expressing cells are selected to survive and differentiate further, whereas pre-TCR(-) cells are "negatively" selected to die. The mechanisms of pre-TCR-mediated survival are poorly understood. Here, we describe the induction of the antiapoptotic gene BCL2A1 (A1)...

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PMID: 15728238
DOI: 10.1084/jem.20041924

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