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Article

Leishmaniasis host response loci (lmr1-3) modify disease severity through a Th1/Th2-independent pathway.

Genes and immunity - 1 Mar 2004

Elso C M, Roberts L J, Smyth G K, Thomson R J, Baldwin T M, Foote S J, Handman E

Abstract excerpt

The severity of disease caused by infection with Leishmania major depends critically on the genetics of the host. Early induction of T helper (Th)1-type immune responses in the resistant C57BL/6 mice and Th2-type responses in the susceptible BALB/c mice are thought to determine cure or disease, respectively. We have previously mapped three host response loci in a genetic cross between C57BL/6 and BALB/c mice, and...

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PMID: 14668789
DOI: 10.1038/sj.gene.6364042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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