Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major.

Parasite immunology - 1 May 1998

Launois P, Conceiçao-Silva F, Himmerlich H, Parra-Lopez C, Tacchini-Cottier F, Louis J A

Abstract excerpt

The murine model of infection with Leishmania major has allowed the demonstration of a causal relationship between, on the one hand, genetically determined resistance to infection and the development of a Th1 CD4+ cell response, and on the other hand, genetically determined susceptibility and Th2 cell maturation. Using this murine model of infection, the role of cytokines in directing the functional...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD4-Positive T-Lymphocytes
Share to Cell Differentiation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Immunity, Innate

Share to Interleukin-4

Share to Mice, Inbred BALB C

Share to Th2 Cells

Source

Identifiers

PMID: 9651923
DOI: 10.1046/j.1365-3024.1998.00153.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Setting in motion the immune mechanisms underlying genetically determined resistance and susceptibility to infection with Leishmania major.PMID 9651923Read ↗

The Regulation of Immunity to Leishmania MajorSemantic proximity Read ↗

The use of the murine model of infection with Leishmania major to reveal the antagonistic effects that IL-4 can exert on T helper cell development and demonstrate that these opposite effects depend upon the nature of the cells targeted for IL-4 signaling.Semantic proximity Read ↗

The murine model of infection with Leishmania major and its importance for the deciphering of mechanisms underlying differences in Th cell differentiation in mice from different genetic backgrounds.Semantic proximity Read ↗

IL-4 instructs TH1 responses and resistance to Leishmania major in susceptible BALB/c mice.Semantic proximity Read ↗

The fate and persistence of Leishmania major in mice of different genetic backgrounds: an example of exploitation of the immune system by intracellular parasites.Semantic proximity Read ↗

IL-4-deficient Balb/c mice resist infection with Leishmania major.Semantic proximity Read ↗

In BALB/c Mice, IL-4 Production During the Initial Phase of Infection with Leishmania major Is Necessary and Sufficient to Instruct Th2 Cell Development Resulting in Progressive DiseaseSemantic proximity Read ↗

Dissociation of disease susceptibility, inflammation and cytokine profile in lmr1/2 congenic mice infected with Leishmania major.Semantic proximity Read ↗

Leishmaniasis host response loci (lmr1-3) modify disease severity through a Th1/Th2-independent pathway.Semantic proximity Read ↗

Genetic susceptibility to Leishmania: IL-12 responsiveness in TH1 cell development.Semantic proximity Read ↗

IL-4- and IL-4 Receptor-Deficient BALB/c Mice Reveal Differences in Susceptibility to Leishmania major Parasite SubstrainsSemantic proximity Read ↗

The relative contribution of IL-4 receptor signaling and IL-10 to susceptibility to Leishmania major.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.