Article
Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis.
Nature reviews. Genetics - 1 Apr 2006
Lipoldová Marie, Demant Peter
Abstract excerpt
Susceptibility to infectious disease is influenced by multiple host genes, most of which are low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied infectious disease with a variety of symptoms and well-defined immunological features. Mouse models of this disease have revealed more than 20 QTLs as being susceptibility genes, studies of which have made important contributions to...
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