Article
Genetic background influences immune responses and disease outcome of cutaneous L. mexicana infection in mice.
International immunology - 1 Oct 2005
Rosas Lucia E, Keiser Tracy, Barbi Joseph, Satoskar Anjali A, Septer Alecia, Kaczmarek Jennifer, Lezama-Davila Claudio M, Satoskar Abhay R
Abstract excerpt
The experimental model of high-dose Leishmania mexicana infection is used frequently to study molecular mechanisms regulating Th2 response since most inbred mice regardless of their genetic background display Th2 cytokine-dependent susceptibility to L. mexicana unlike Leishmania major. Here, we analyzed the course of L. mexicana infection in BALB/c, C57BL/6 and CBA/J mouse strains using low-dose ear infection...
Topics
- Animals
- Antigens, Protozoan
- Cytokines
- Genetic Predisposition to Disease
- Kinetics
- Leishmania mexicana
- Leishmaniasis, Cutaneous
- Lymph Nodes
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C57BL
- Mice, Inbred CBA
- STAT6 Transcription Factor