Article
Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects.
Genes and immunity - 1 Apr 2006
Havelková H, Badalová J, Svobodová M, Vojtíková J, Kurey I, Vladimirov V, Demant P, Lipoldová M
Abstract excerpt
Symptoms of human leishmaniasis range from subclinical to extensive systemic disease with splenomegaly, hepatomegaly, skin lesions, anemia and hyperglobulinemia, but the basis of this variation is unknown. Association of progression of the disease with Th2 lymphocyte response was reported in mice but not in humans. As most genetic studies in Leishmania major (L. major)-infected mice were restricted to skin...
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