Article
Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.
Cancer cell - 1 Nov 2003
Chipuk Jerry E, Maurer Ulrich, Green Douglas R, Schuler Martin
Abstract excerpt
Recent efforts to develop pharmacologic agents that restore function to mutant forms of p53 hold significant promise in cancer therapy. Here, we examine the effects of such pharmacologic activation of p53 function using a small molecule, PRIMA-1, and a model system employing a p53 protein fused to a mutant steroid binding domain of the murine estrogen receptor (p53ERtam) that renders it responsive only in the...
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