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Article

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.

Oncogene - 4 Mar 2010

Lambert J M R, Moshfegh A, Hainaut P, Wiman K G, Bykov V J N

Abstract excerpt

The low molecular weight compound PRIMA-1(MET) reactivates mutant p53 and triggers mutant p53-dependent apoptosis in human tumor cells. We investigated the effect of PRIMA-1(MET) on global gene expression using microarray analysis of Saos-2 cells expressing His273 mutant p53 and parental p53 null Saos-2 cells. PRIMA-1(MET) affected transcription of a significantly larger number of genes in the mutant...

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Share to Apoptosis
Share to XBP1 gene
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 19946333
DOI: 10.1038/onc.2009.425

Genes

MET
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.PMID 19946333Read ↗

PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax.Semantic proximity Read ↗

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