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Article

PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax.

Biochemical and biophysical research communications - 5 Jan 2007

Wang Tao, Lee Kyunghee, Rehman Abdur, Daoud Sayed S

Abstract excerpt

The p53 protein plays a major role in the maintenance of genome stability in mammalian cells. Mutations of p53 occur in over 40% of breast cancers and are indicative of tumor resistance to chemotherapeutic agents. Recently, there has been a high degree of interest in pharmacological approaches for restoring the normal function to mutant p53. The low molecular weight compound p53 reactivation and induction of...

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Identifiers

PMID: 17113036
DOI: 10.1016/j.bbrc.2006.11.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PRIMA-1 induces apoptosis by inhibiting JNK signaling but promoting the activation of Bax.PMID 17113036Read ↗

PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein.Semantic proximity Read ↗

Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.Semantic proximity Read ↗

Prima-1 induces apoptosis in bladder cancer cell lines by activating p53.Semantic proximity Read ↗

Proteomic identification of heat shock protein 90 as a candidate target for p53 mutation reactivation by PRIMA-1 in breast cancer cells.Semantic proximity Read ↗

PRIMA-1 and PRIMA-1Met (APR-246): From Mutant/Wild Type p53 Reactivation to Unexpected Mechanisms Underlying Their Potent Anti-Tumor Effect in Combinatorial TherapiesSemantic proximity Read ↗

PRIMA-1 cytotoxicity correlates with nucleolar localization and degradation of mutant p53 in breast cancer cells.Semantic proximity Read ↗

Pharmacologic activation of p53 elicits Bax-dependent apoptosis in the absence of transcription.Semantic proximity Read ↗

PRIMA-1 synergizes olaparib-induced cell death in p53 mutant triple negative human breast cancer cell line via restoring p53 function, arresting cell cycle, and inducing apoptosisSemantic proximity Read ↗

PRIMA-1, a mutant p53 reactivator, induces apoptosis and enhances chemotherapeutic cytotoxicity in pancreatic cancer cell lines.Semantic proximity Read ↗

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.Semantic proximity Read ↗

MicroRNA-34a is an important component of PRIMA-1-induced apoptotic network in human lung cancer cells.Semantic proximity Read ↗

Selective induction of apoptosis in mutant p53 premalignant and malignant cancer cells by PRIMA-1 through the c-Jun-NH2-kinase pathwaySemantic proximity Read ↗

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