Article
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.
Nature medicine - 1 Mar 2002
Bykov Vladimir J N, Issaeva Natalia, Shilov Alexandre, Hultcrantz Monica, Pugacheva Elena, Chumakov Peter, Bergman Jan, Wiman Klas G, Selivanova Galina
Abstract excerpt
The tumor suppressor p53 inhibits tumor growth primarily through its ability to induce apoptosis. Mutations in p53 occur in at least 50% of human tumors. We hypothesized that reactivation of mutant p53 in such tumors should trigger massive apoptosis and eliminate the tumor cells. To test this, we screened a library of low-molecular-weight compounds in order to identify compounds that can restore wild-type...
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