Article
p53 Immunostaining guided laser capture microdissection (p53-LCM) defines the presence of p53 gene mutations in focal regions of primary prostate cancer positive for p53 protein.
Prostate cancer and prostatic diseases - 1 Jan 2003
Griewe G L, Dean R C, Zhang W, Young D, Sesterhenn I A, Shanmugam N, McLeod D G, Moul J W, Srivastava S
Abstract excerpt
OBJECTIVES: A wide range of p53 mutations (5-65%), detected by various methods, has been reported in primary prostate cancers (CaP). IHC staining of radical prostatectomy specimens shows marked heterogeneity of focally distributed p53-positive cells. However, a significant relationship between the focal staining of p53 and cancer recurrence after radical prostatectomy has been noted. Increased frequency of p53...
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