Article
Complete transposition requires four active monomers in the mu transposase tetramer.
Genes & development - 15 Oct 1994
Baker T A, Kremenstova E, Luo L
Abstract excerpt
A tetramer of Mu transposase (MuA) cleaves and joins multiple DNA strands to promote transposition. Derivatives of MuA altered at two acidic residues that are conserved among transposases and retroviral integrases form tetramers but are defective in both cleavage and joining. These mutant protein...
Topics
- Bacteriophage mu
- Base Sequence
- Binding Sites
- DNA Nucleotidyltransferases
- DNA, Single-Stranded
- DNA, Viral
- Genes, Viral
- Integrases
- Models, Biological
- Molecular Sequence Data
- Mutation
- Nucleotidyltransferases
- Protein Conformation
- Recombinases
- Transposases